RapamycinFungusV1, Main, Exploration, bibRecord, 000461

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome.

Identifieur interne : 000461 ( Main/Exploration ); précédent : 000460; suivant : 000462

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome.

Auteurs : Louis-Philippe Leroux [Canada] ; Julie Lorent [Suède] ; Tyson E. Graber [Canada] ; Visnu Chaparro [Canada] ; Laia Masvidal [Suède] ; Maria Aguirre [Canada] ; Bruno D. Fonseca [Canada] ; Léon C. Van Kempen [Canada, Pays-Bas] ; Tommy Alain [Canada] ; Ola Larsson [Suède] ; Maritza Jaramillo [Canada]

Source :

Infection and immunity [ 1098-5522 ] ; 2018.

RBID : pubmed:29967092

Descripteurs français

KwdFr :
- Animaux (MeSH), Biosynthèse des protéines (génétique), Cellules cultivées (MeSH), Interactions hôte-parasite (MeSH), Macrophages (parasitologie), Protéines de protozoaire (immunologie), Protéines mitochondriales (génétique), Souris (MeSH), Souris de lignée C57BL (MeSH), Souris knockout (MeSH), Séquence d'oligopyrimidines en région 5' terminale d'ARN (MeSH), Sérine-thréonine kinases TOR (génétique), Toxoplasma (pathogénicité), Transduction du signal (MeSH).
MESH :
- génétique : Biosynthèse des protéines, Protéines mitochondriales, Sérine-thréonine kinases TOR.
- immunologie : Protéines de protozoaire.
- parasitologie : Macrophages.
- pathogénicité : Toxoplasma.
- Animaux, Cellules cultivées, Interactions hôte-parasite, Souris, Souris de lignée C57BL, Souris knockout, Séquence d'oligopyrimidines en région 5' terminale d'ARN, Transduction du signal.

English descriptors

KwdEn :
- Animals (MeSH), Cells, Cultured (MeSH), Host-Parasite Interactions (MeSH), Macrophages (parasitology), Mice (MeSH), Mice, Inbred C57BL (MeSH), Mice, Knockout (MeSH), Mitochondrial Proteins (genetics), Protein Biosynthesis (genetics), Protozoan Proteins (immunology), RNA 5' Terminal Oligopyrimidine Sequence (MeSH), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (genetics), Toxoplasma (pathogenicity).
MESH :
- chemical , genetics : Mitochondrial Proteins, TOR Serine-Threonine Kinases.
- genetics : Protein Biosynthesis.
- chemical , immunology : Protozoan Proteins.
- parasitology : Macrophages.
- pathogenicity : Toxoplasma.
- Animals, Cells, Cultured, Host-Parasite Interactions, Mice, Mice, Inbred C57BL, Mice, Knockout, RNA 5' Terminal Oligopyrimidine Sequence, Signal Transduction.

Abstract

The intracellular parasite Toxoplasma gondii promotes infection by targeting multiple host cell processes; however, whether it modulates mRNA translation is currently unknown. Here, we show that infection of primary murine macrophages with type I or II T. gondii strains causes a profound perturbation of the host cell translatome. Notably, translation of transcripts encoding proteins involved in metabolic activity and components of the translation machinery was activated upon infection. In contrast, the translational efficiency of mRNAs related to immune cell activation and cytoskeleton/cytoplasm organization was largely suppressed. Mechanistically, T. gondii bolstered mechanistic target of rapamycin (mTOR) signaling to selectively activate the translation of mTOR-sensitive mRNAs, including those with a 5'-terminal oligopyrimidine (5' TOP) motif and those encoding mitochondrion-related proteins. Consistent with parasite modulation of host mTOR-sensitive translation to promote infection, inhibition of mTOR activity suppressed T. gondii replication. Thus, selective reprogramming of host mRNA translation represents an important subversion strategy during T. gondii infection.

DOI: 10.1128/IAI.00244-18
PubMed: 29967092
PubMed Central: PMC6105892

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000514
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Le document en format XML

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<author><name sortKey="Fonseca, Bruno D" sort="Fonseca, Bruno D" uniqKey="Fonseca B" first="Bruno D" last="Fonseca">Bruno D. Fonseca</name>
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<author><name sortKey="Van Kempen, Leon C" sort="Van Kempen, Leon C" uniqKey="Van Kempen L" first="Léon C" last="Van Kempen">Léon C. Van Kempen</name>
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<wicri:noRegion>Quebec</wicri:noRegion>
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<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, McGill University, Montreal, Quebec, Canada.</nlm:affiliation>
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<wicri:regionArea>Department of Pathology, McGill University, Montreal, Quebec</wicri:regionArea>
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<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology and Medical Biology, University Medical Centre, Groningen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology and Medical Biology, University Medical Centre, Groningen</wicri:regionArea>
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<author><name sortKey="Alain, Tommy" sort="Alain, Tommy" uniqKey="Alain T" first="Tommy" last="Alain">Tommy Alain</name>
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<author><name sortKey="Larsson, Ola" sort="Larsson, Ola" uniqKey="Larsson O" first="Ola" last="Larsson">Ola Larsson</name>
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<country xml:lang="fr">Suède</country>
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<author><name sortKey="Jaramillo, Maritza" sort="Jaramillo, Maritza" uniqKey="Jaramillo M" first="Maritza" last="Jaramillo">Maritza Jaramillo</name>
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<country wicri:rule="url">Canada</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Host-Parasite Interactions, Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome.</title>
<author><name sortKey="Leroux, Louis Philippe" sort="Leroux, Louis Philippe" uniqKey="Leroux L" first="Louis-Philippe" last="Leroux">Louis-Philippe Leroux</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Host-Parasite Interactions, Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre for Host-Parasite Interactions, Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec</wicri:regionArea>
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<author><name sortKey="Lorent, Julie" sort="Lorent, Julie" uniqKey="Lorent J" first="Julie" last="Lorent">Julie Lorent</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm</wicri:regionArea>
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</placeName>
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<author><name sortKey="Graber, Tyson E" sort="Graber, Tyson E" uniqKey="Graber T" first="Tyson E" last="Graber">Tyson E. Graber</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario</wicri:regionArea>
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<author><name sortKey="Chaparro, Visnu" sort="Chaparro, Visnu" uniqKey="Chaparro V" first="Visnu" last="Chaparro">Visnu Chaparro</name>
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<country xml:lang="fr">Canada</country>
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<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Host-Parasite Interactions, Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre for Host-Parasite Interactions, Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Masvidal, Laia" sort="Masvidal, Laia" uniqKey="Masvidal L" first="Laia" last="Masvidal">Laia Masvidal</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aguirre, Maria" sort="Aguirre, Maria" uniqKey="Aguirre M" first="Maria" last="Aguirre">Maria Aguirre</name>
<affiliation wicri:level="1"><nlm:affiliation>Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lady Davis Institute, Jewish General Hospital, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fonseca, Bruno D" sort="Fonseca, Bruno D" uniqKey="Fonseca B" first="Bruno D" last="Fonseca">Bruno D. Fonseca</name>
<affiliation wicri:level="1"><nlm:affiliation>Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
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<author><name sortKey="Van Kempen, Leon C" sort="Van Kempen, Leon C" uniqKey="Van Kempen L" first="Léon C" last="Van Kempen">Léon C. Van Kempen</name>
<affiliation wicri:level="1"><nlm:affiliation>Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lady Davis Institute, Jewish General Hospital, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, McGill University, Montreal, Quebec, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pathology, McGill University, Montreal, Quebec</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology and Medical Biology, University Medical Centre, Groningen, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology and Medical Biology, University Medical Centre, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alain, Tommy" sort="Alain, Tommy" uniqKey="Alain T" first="Tommy" last="Alain">Tommy Alain</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Larsson, Ola" sort="Larsson, Ola" uniqKey="Larsson O" first="Ola" last="Larsson">Ola Larsson</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jaramillo, Maritza" sort="Jaramillo, Maritza" uniqKey="Jaramillo M" first="Maritza" last="Jaramillo">Maritza Jaramillo</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada maritza.jaramillo@iaf.inrs.ca.</nlm:affiliation>
<country wicri:rule="url">Canada</country>
<wicri:regionArea>Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
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<country xml:lang="fr">Canada</country>
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<wicri:noRegion>Quebec</wicri:noRegion>
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<series><title level="j">Infection and immunity</title>
<idno type="eISSN">1098-5522</idno>
<imprint><date when="2018" type="published">2018</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Host-Parasite Interactions (MeSH)</term>
<term>Macrophages (parasitology)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Mice, Knockout (MeSH)</term>
<term>Mitochondrial Proteins (genetics)</term>
<term>Protein Biosynthesis (genetics)</term>
<term>Protozoan Proteins (immunology)</term>
<term>RNA 5' Terminal Oligopyrimidine Sequence (MeSH)</term>
<term>Signal Transduction (MeSH)</term>
<term>TOR Serine-Threonine Kinases (genetics)</term>
<term>Toxoplasma (pathogenicity)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Biosynthèse des protéines (génétique)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Interactions hôte-parasite (MeSH)</term>
<term>Macrophages (parasitologie)</term>
<term>Protéines de protozoaire (immunologie)</term>
<term>Protéines mitochondriales (génétique)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Souris knockout (MeSH)</term>
<term>Séquence d'oligopyrimidines en région 5' terminale d'ARN (MeSH)</term>
<term>Sérine-thréonine kinases TOR (génétique)</term>
<term>Toxoplasma (pathogénicité)</term>
<term>Transduction du signal (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Mitochondrial Proteins</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Protein Biosynthesis</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Biosynthèse des protéines</term>
<term>Protéines mitochondriales</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Protéines de protozoaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Protozoan Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Toxoplasma</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Toxoplasma</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Host-Parasite Interactions</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>RNA 5' Terminal Oligopyrimidine Sequence</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Interactions hôte-parasite</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Séquence d'oligopyrimidines en région 5' terminale d'ARN</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">The intracellular parasite <i>Toxoplasma gondii</i>
 promotes infection by targeting multiple host cell processes; however, whether it modulates mRNA translation is currently unknown. Here, we show that infection of primary murine macrophages with type I or II <i>T. gondii</i>
 strains causes a profound perturbation of the host cell translatome. Notably, translation of transcripts encoding proteins involved in metabolic activity and components of the translation machinery was activated upon infection. In contrast, the translational efficiency of mRNAs related to immune cell activation and cytoskeleton/cytoplasm organization was largely suppressed. Mechanistically, <i>T. gondii</i>
 bolstered mechanistic target of rapamycin (mTOR) signaling to selectively activate the translation of mTOR-sensitive mRNAs, including those with a 5'-terminal oligopyrimidine (5' TOP) motif and those encoding mitochondrion-related proteins. Consistent with parasite modulation of host mTOR-sensitive translation to promote infection, inhibition of mTOR activity suppressed <i>T. gondii</i>
 replication. Thus, selective reprogramming of host mRNA translation represents an important subversion strategy during <i>T. gondii</i>
 infection.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29967092</PMID>
<DateCompleted><Year>2019</Year>
<Month>03</Month>
<Day>05</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>03</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1098-5522</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>86</Volume>
<Issue>9</Issue>
<PubDate><Year>2018</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>Infection and immunity</Title>
<ISOAbbreviation>Infect Immun</ISOAbbreviation>
</Journal>
<ArticleTitle>The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">e00244-18</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1128/IAI.00244-18</ELocationID>
<Abstract><AbstractText>The intracellular parasite <i>Toxoplasma gondii</i>
 promotes infection by targeting multiple host cell processes; however, whether it modulates mRNA translation is currently unknown. Here, we show that infection of primary murine macrophages with type I or II <i>T. gondii</i>
 strains causes a profound perturbation of the host cell translatome. Notably, translation of transcripts encoding proteins involved in metabolic activity and components of the translation machinery was activated upon infection. In contrast, the translational efficiency of mRNAs related to immune cell activation and cytoskeleton/cytoplasm organization was largely suppressed. Mechanistically, <i>T. gondii</i>
 bolstered mechanistic target of rapamycin (mTOR) signaling to selectively activate the translation of mTOR-sensitive mRNAs, including those with a 5'-terminal oligopyrimidine (5' TOP) motif and those encoding mitochondrion-related proteins. Consistent with parasite modulation of host mTOR-sensitive translation to promote infection, inhibition of mTOR activity suppressed <i>T. gondii</i>
 replication. Thus, selective reprogramming of host mRNA translation represents an important subversion strategy during <i>T. gondii</i>
 infection.</AbstractText>
<CopyrightInformation>Copyright © 2018 American Society for Microbiology.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Leroux</LastName>
<ForeName>Louis-Philippe</ForeName>
<Initials>LP</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-9736-1827</Identifier>
<AffiliationInfo><Affiliation>Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Host-Parasite Interactions, Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Lorent</LastName>
<ForeName>Julie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Graber</LastName>
<ForeName>Tyson E</ForeName>
<Initials>TE</Initials>
<AffiliationInfo><Affiliation>Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chaparro</LastName>
<ForeName>Visnu</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Host-Parasite Interactions, Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Masvidal</LastName>
<ForeName>Laia</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aguirre</LastName>
<ForeName>Maria</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fonseca</LastName>
<ForeName>Bruno D</ForeName>
<Initials>BD</Initials>
<AffiliationInfo><Affiliation>Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Kempen</LastName>
<ForeName>Léon C</ForeName>
<Initials>LC</Initials>
<AffiliationInfo><Affiliation>Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pathology, McGill University, Montreal, Quebec, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pathology and Medical Biology, University Medical Centre, Groningen, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alain</LastName>
<ForeName>Tommy</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Larsson</LastName>
<ForeName>Ola</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jaramillo</LastName>
<ForeName>Maritza</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-1910-5684</Identifier>
<AffiliationInfo><Affiliation>Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada maritza.jaramillo@iaf.inrs.ca.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Host-Parasite Interactions, Institut National de la Recherche Scientifique-Institut Armand Frappier, Laval, Quebec, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>08</Month>
<Day>22</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Infect Immun</MedlineTA>
<NlmUniqueID>0246127</NlmUniqueID>
<ISSNLinking>0019-9567</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D024101">Mitochondrial Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015800">Protozoan Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="C546843">mTOR protein, mouse</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006790" MajorTopicYN="Y">Host-Parasite Interactions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName>
<QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D024101" MajorTopicYN="N">Mitochondrial Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014176" MajorTopicYN="N">Protein Biosynthesis</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015800" MajorTopicYN="N">Protozoan Proteins</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D038641" MajorTopicYN="N">RNA 5' Terminal Oligopyrimidine Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014122" MajorTopicYN="N">Toxoplasma</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Toxoplasma gondii</Keyword>
<Keyword MajorTopicYN="Y">host-pathogen interactions</Keyword>
<Keyword MajorTopicYN="Y">mTOR</Keyword>
<Keyword MajorTopicYN="Y">macrophages</Keyword>
<Keyword MajorTopicYN="Y">translational control</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>03</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>06</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>7</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>3</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>7</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
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<ArticleId IdType="doi">10.1128/IAI.00244-18</ArticleId>
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The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome.

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome.

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